Prediabetes Raises the Risk of All-Cause Mortality, and Diabetes-Related Conditions
The CDC estimates
that 96
million American adults have prediabetes.
And most persons with prediabetes don't know that
they have the condition. The CDC’s Diabetes
Prevention Program study that took place between
1996 and 2002 showed that lifestyle intervention
can reduce the risk of progression from
prediabetes to diabetes by 58% compared to people
with prediabetes who were receiving usual care.
And a recent study
suggests that prediabetes raises the risk of
all-cause mortality, comorbidities and
complications.
The study was carried out by analyzing the results
from different meta-analyses to determine how
prediabetes is related to new cases of
complications typically associated with diabetes.
The researchers studied 4807 articles containing
prediabetes-related meta-analyses. And the
researchers narrowed the number of articles that
fit the selection criteria to 16 articles, from
which 95 meta-analyses were chosen.
The researchers concluded that “Prediabetes was
associated with a higher relative risk of
all-cause mortality and higher incidences of CV
[cardiovascular] events, CHD [coronary heart
disease], stroke, heart failure, atrial
fibrillation, chronic kidney disease, total
cancer, liver cancer, hepatocellular carcinoma,
breast cancer and all-cause dementia with moderate
certainty of evidence."
The researchers indicated that the incidence of the
comorbidities and complications was lower for
prediabetes than type 2 diabetes "suggesting
a dose–response gradient in the relationship with
complications."
The meta-analyses study highlights the importance
of addressing prediabetes. We know that
prediabetes raises the risk of diabetes. But the
study shows that prediabetes raises the risk of
other diseases. Therefore, healthcare providers
should counsel at-risk prediabetes patients. They
should work with the patients, if appropriate, to
get the patients into a diabetes prevention
program.
These programs can delay or prevent diabetes which
could increase the lifespan of a person with
prediabetes. Delaying or preventing diabetes can
not only increase a person’s lifespan, it can also
lower the person’s healthcare costs.
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